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HBV/HCV - Chronic Viral Hepatitis

The Silent Killer" -  a serious disorder caused by HBV and HCV that has a general tendency to progress to hepatic cirrhosis and possibly even primary liver cancer.

BioMonde's response!
The Global Burden of viral hepatitis HBV and HCV

The commonest chronic viral infections are associated with Hepatitis B (HBV) with 170 million people and Hepatitis C (HCV) with up to 300 chronically infected worldwide. Between 8,000 and 10,000 people die of hepatitis C and 5,000 people die of hepatitis B annually in the US.

Problems associated with anti-viral treatments for HBV and HCV
Chronic active hepatitis;
Non-response;
High occurrence of relapse;
Adverse side-effects;
Badly tolerated;
Limited beneficial effects;
Not readily available;
Expensive;
Broad exclusion criteria;
Inconvenient delivery methods.

fda

FDA-approved (HBV) Treatments

Baraclude (entecavir)
EpivirHBV (lamivudine; 3TC)
Intron A (interferon alfa-2b)
Hepsera (adefovir dipivoxil)
Pegasys (peginterferon alfa-2a)
Tyzeka (telbivudine)

FDA-approved (HCV) Monotherapies

Intron A
Roferon
Infergen
Pegasys
PEG-Intron

FDA-approved (HCV) Combination Therapies

Pegasys + Copegus
PEG-Intron + Rebetol
Intron A + Rebetol
Roferon A + Ribavirin

Development of a optimized, safe, effective and affordable class of novel anti-hepatoinflammatory (anti-hepatitis) and hepatoprotector umbelliferone derivatives (4-meythylumbellierone).
4-mu

  • a adjunct to anti-viral treatment;
  • a therapy for non-responders to anti-viral (interferon) treatment;
  • a therapy for HBV and HCV induced Acute and Chronic Viral Hepatitis;
  • a therapy for any co-hosted combination of: HBV, HCV, HIV, Cirrhosis, and Liver Cancer;
  • a prophylaxis therapy for HBV and HCV antiviral treatment to maximize the efficacy and minimize the adverse side effects of interferon and other antiviral drugs;
  • a therapy to manage Liver Cirrhosis;
  • a therapy where anti-viral treatment was declined due to exclusion criteria such as diabetic, drug, alcohol and other problems.

Whilst anti-viral treatment targets the virus that causes Chronic Viral Hepatitis, BioMonde focuses on managing Chronic Viral Hepatitis.

Umbelliferone derivatives (4-meythylumbellierone) can greatly lessen liver inflammation, Hepatitis, and dramatically improve elevated liver enzymes, which are indications of Liver damage associated with Chronic Viral Hepatitis, HBV and HCV. By controlling liver inflammation and liver enzymes, it is possible to prevent and minimize liver scarring (fibrosis), and progression to cirrhosis and liver cancer, irrespective of viral loads.

Umbelliferone derivatives (4-meythylumbellierone) also stimulate liver function, including the regeneration tissue damage. Whilst is may not be possible to repair liver scarring (fibrosis) associated with cirrhosis, it is possible to slow its progression.

BioMonde derivatives are not only an ideal prophylaxis and adjunct to anti-viral treatment such as Interferon, they offer a viable and effective option for Interferon non-responders and many previously excluded from anti-viral treatment. Consequently, BioMonde's approach means that more HBV and HCV patients can have access to effective healthcare.

REFERENCE MATERIAL

Published, Peer Reviewed Studies and Medical Opinion click-here


View our product pipeline click-here

Products containing umbelliferone derivatives (4-Methylumbelliferone) click-here

HEPARVIT™ ProHEP

    HBV Virus
              HCV Virus

hbvhcv

Medical research...........

Indicates that umbelliferone derivatives (4-meythylumbellierone) administered with or without anti-viral treatment greatly improves the underlying symptoms associated with Chronic Viral Hepatitis and the progression of HBV/HCV.

  • diminishes liver inflammation (Hepatitis);
  • lowers elevated liver enzymes;
  • lessens abdominal pain;
  • minimizes liver cell damage;
  • stimulates cellular regeneration in the liver;
  • decreases lethargy and fatigue associated with HBV, HCV, and anti-viral drugs;
  • protects the liver against the toxic affects of drugs, alcohol, anabolic steroids, etc.;
  • helps normalize liver function;
  • improves the efficacy of anti-viral drugs by improving tolerance, reducing adverse side-effects and toxicity.